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Total 43767 results found since Jan 2013.
Review of gestational diabetes mellitus effects on vascular structure and function
Vascular dysfunction has been described in women with a history of gestational diabetes mellitus. Furthermore, previous gestational diabetes mellitus increases the risk of developing Type 2 diabetes mellitus, a risk factor for cardiovascular disease. Factors contributing to vascular changes remain uncertain. The aim of this review was to summarize vascular structure and function changes found to occur in women with previous gestational diabetes mellitus and to identify factors that contribute to vascular dysfunction. A systematic search of electronic databases yielded 15 publications from 1998 to March 2014 that met the in...
Source: Diabetes and Vascular Disease Research - April 14, 2016 Category: Endocrinology Authors: Jensen, L. A., Chik, C. L., Ryan, E. A. Tags: Review Article Source Type: research
Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease
CONCLUSIONS: Our analysis showed the existence of TLOs across 5 models of vascular diseases. The mechanisms that support TLOs formation in different models are heterogeneous. This study could be a valuable resource for understanding and discovering new therapeutic targets for various forms of vascular disease.PMID:37589134 | DOI:10.1161/ATVBAHA.123.318762
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Xuejing Sun Yao Lu Junru Wu Qing Wen Zhengxin Li Yan Tang Yunmin Shi Tian He Lun Liu Wei Huang Chunyan Weng Qing Wu Qingzhong Xiao Hong Yuan Qingbo Xu Jingjing Cai Source Type: research
Sitagliptin, a dipeptidyl peptidase-4 inhibitor, attenuates apoptosis of vascular smooth muscle cells and reduces atherosclerosis in diabetic apolipoprotein E-deficient mice
In conclusion, these results indicated that the anti-atherosclerotic effect of sitagliptin is mediated, at least in part, by its inhibition of VSMCs apoptosis.PMID:33781961 | DOI:10.1016/j.vph.2021.106854
Source: Vascular Pharmacology - March 30, 2021 Category: Drugs & Pharmacology Authors: Bo Li Yan Rong Luo Qian Zhang Shi Hui Fu Yun Dai Chen Jing Wen Tian Yi Guo Source Type: research
A Novel Mechanism for Vascular Insulin Resistance in Normotensive Young SHRs: Hypoadiponectinemia and Resultant APPL1 Downregulation Blood Vessels
In conclusion, hypoadiponectinemia induces APPL1 downregulation in the resistance vessels, contributing to the development of vascular insulin resistance by differentially modulating the Akt/endothelial NO synthase/NO and ERK1/2/endothelin-1 pathways in vascular endothelium in normotensive ySHRs.
Source: Hypertension - April 17, 2013 Category: Cardiology Authors: Xing, W., Yan, W., Liu, P., Ji, L., Li, Y., Sun, L., Tao, L., Zhang, H., Gao, F. Tags: Animal models of human disease, Endothelium/vascular type/nitric oxide Blood Vessels Source Type: research
Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results from the SEARCH for Diabetes in Youth.
Conclusions/Interpretation:In this systematic study of MODY in a large pediatric US diabetes cohort, unselected by referral pattern or family history, MODY was usually misdiagnosed and incorrectly treated with insulin. While many type 2 diabetes-like metabolic features were less common in the mutation-positive group, no single characteristic identified all patients with mutations. Clinicians should be alert to the possibility of MODY diagnosis, particularly in antibody negative youth with diabetes.
PMID: 23771925 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - June 14, 2013 Category: Endocrinology Authors: Gilliam LK, Pihoker C, Ellard S, Hattersley AT, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE, for the SEARCH for Diabetes in Youth Study Group Tags: J Clin Endocrinol Metab Source Type: research
Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet-Induced Arterial Stiffening in Female Mice Vascular Structure and Function
Women are especially predisposed to development of arterial stiffening secondary to obesity because of consumption of excessive calories. Enhanced activation of vascular mineralocorticoid receptors impairs insulin signaling, induces oxidative stress, inflammation, and maladaptive immune responses. We tested whether a subpressor dose of mineralocorticoid receptor antagonist, spironolactone (1 mg/kg per day) prevents aortic and femoral artery stiffening in female C57BL/6J mice fed a high-fat/high-sugar western diet (WD) for 4 months (ie, from 4–20 weeks of age). Aortic and femoral artery stiffness were assessed using u...
Source: Hypertension - June 10, 2015 Category: Cardiology Authors: DeMarco, V. G., Habibi, J., Jia, G., Aroor, A. R., Ramirez-Perez, F. I., Martinez-Lemus, L. A., Bender, S. B., Garro, M., Hayden, M. R., Sun, Z., Meininger, G. A., Manrique, C., Whaley-Connell, A., Sowers, J. R. Tags: Endothelium/vascular type/nitric oxide Vascular Structure and Function Source Type: research
Abstract P200: Endothelial Estrogen Receptor Alpha Does Not Protect Female Mice Against Western Diet Induced Vascular Stiffness Session Title: Receptors and Signal Transduction/Vascular Biology and Stiffness
Conclusion: Endothelial ERα does not protect females from vascular stiffness induced by a WD. Indeed, the present data suggest a predisposition toward protection of rodent lacking ERα in conditions of insulin resistance.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Manrique, C., Lastra, G., Haertling, D., DeMarco, V., Aroor, A., Jia, G., Ramirez-Perez, F. I., Martinez-Lemus, L., Karas, R., Chambon, P., Sowers, J. Tags: Session Title: Receptors and Signal Transduction/Vascular Biology and Stiffness Source Type: research
Abstract P257: High Fat Diet Induces Metabolic Syndrome-Like Phenotype Associated with Adverse Micro- and Macro-Vascular Remodeling Session Title: Vascular Remodeling and Dysfunction/Endothelin Factors
Metabolic diseases such as type 2 diabetes (T2DM), hypertension, and metabolic syndrome (MetS) have been associated with vascular disease, and we have previously demonstrated vascular-bed-specific remodeling in both mouse and porcine models of T2DM and MetS. The aim of this study was to determine whether high-fat diet would induce MetS-associated adverse micro- and macro-vascular remodeling and mechanics in mice. Three week old male C57BL/6J mouse siblings were randomized to receive either a normal low-fat (LFD: 10% fat) or high-fat (HFD: 60% fat) diet for 20 weeks (n=7-10 per group). HFD induced a MetS-like phenotype char...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Trask, A. J. Tags: Session Title: Vascular Remodeling and Dysfunction/Endothelin Factors Source Type: research
Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis.
CONCLUSIONS: These novel findings demonstrate that DDR1 promotes RUNX2 activity and atherosclerotic vascular calcification in diabetes mellitus via phosphoinositide 3-kinase/Akt signaling.
PMID: 29930002 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 21, 2018 Category: Cardiology Authors: Lino M, Wan MH, Rocca AS, Ngai D, Shobeiri N, Hou G, Ge C, Franceschi RT, Bendeck MP Tags: Arterioscler Thromb Vasc Biol Source Type: research
